A child and a man died when a minibus collided with a car in Cheshire in the early hours of Sunday morning.
Nine people were taken to hospital to be treated after the crash on the A34 Melrose Way in Alderley Edge at 12.04am.
A man was taken to Manchester Royal Infirmary and a child was taken to Royal Manchester Children's Hospital.
Seven others were taken to Macclesfield Hospital with minor injuries.
Their current conditions are unknown.
A spokesperson for North West Ambulance Service said it was a "significant incident" and that "multiple resources" had attended.
Firefighters were called and helped free casualties trapped in the vehicles.
A spokesperson said: "Police investigating a serious collision in Alderley Edge are appealing for witnesses.
"The collision involved a car and a minibus. A number of casualties were treated at the scene and taken to hospital."
The road was temporarily shut between Alderley Park roundabout and the Alderley Edge roundabout while emergency services attended.
A number of locals posted online commenting that the area has a reputation for accidents and near-misses.
"There's so many near misses on the bypass because its not a duel carriageway [sic]," wrote one.
"There are many accidents here because people cut other up when not using the right lane," said another.
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A third driver wrote: "I used to travel along here everyday and so many times I've had cars and vans overtake and [had] near miss head on crash[es] with my car."
:: Anyone who witnessed the collision is asked to contact Cheshire Police on 101 quoting IML 231304.