The Red Devils are sweating on the fitness of five stars, including Aaron Wan-Bissaka and Paul Pogba.
There are also concerns about the fitness of Luke Shaw, Anthony Martial and Jesse Lingard, according to the Mirror.
Right-back Wan-Bissaka has been a key performer for Ole Gunnar Solskjaer so far this season, but was forced to withdraw from the England squad.
The 21-year-old picked up a back problem, with his club team-mate Jesse Lingard also sent home from the England camp.
Illness forced Lingard to sit out the international fixtures against Bulgaria and Kosovo, while left-back Shaw is struggling with a hamstring problem.
Pogba withdrew from the France squad with an ankle problem. Upfront, Martial missed Uniteds last game against Southampton after picking up a knock in the defeat to Crystal Palace last month.
United welcome Leicester City to Old Trafford in their first game back after the international break on the hunt for their first win since early August.
Solskjaer is under pressure to produce results after a hugely promising 4-0 opening day victory over Chelsea.
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